Supervisor’s research interests

I have started two research laboratories in Moscow:

Mechanisms of Tumor Cell Death at Blokhin Cancer Center.

Molecular Oncobiology at the Institute of Gene Biology, Russian Academy of Sciences. Also, I founded a cancer biology group at ITRMO University, St.Petersburg and a team at the Dept. of Chemistry, Moscow State University. My research interests include molecular and cell biology of anticancer drug resistance, anticancer drug design, and medicinal chemistry of anticancer drugs. Currently these multidisciplinary groups consist of researchers <35 years, MS and PhD students.

Research highlights

We collaborate with international groups in the US and France. In 2018-2020 we have a megagrant funded by the Russian Federation Government on transcriptional reprogramming in cancer (Prof.I.Roninson, supervisor; USA). Also, we have support from RFBR.

Main publications

• Tikhomirov A.S.et al. Synthesis and biological evaluation of anticancer 4,11-diaminoanthra[2,3-b]furan-5,10-diones: focus on the SIRT1-mediated mechanism of tumor cell death. J. Med. Chem., 2015, 58, 9522-9534.
• Esvan Y.J.et al. New pyrazole derivative of the staurosporine aglycon K252c: inhibition of Pim protein kinases and cytotoxic properties. Bioorg. Med. Chem., 2016, 24, 3116-3124.
• Beniaminov A.D.et al. Divalent cations are dispensable for binding to DNA of a novel positively charged olivomycin A derivative. PLoS One 2018, 13, 2, e0191923.
• Ivanova E.S. et al. PF-114, a new selective inhibitor of BCR-Abl tyrosine kinase, is a potent inducer of apoptosis in chronic myelogenous leukemia cells. Int. J. Oncol., 2019, 55, 289-297. DOI: 10.3892/ijo.2019.4801.
• Sagnou M. et al. Novel curcumin derivatives as P-glycoprotein inhibitors: molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin. Eur. J. Med. Chem., 2020, 198, 2020, doi.org/10.1016/j.ejmech.2020.112331.
• Tikhomirov A.S.et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: synthesis and antitumor activities. Eur.J. Med. Chem., 2020, doi.org/10.1016/j.ejmech.2020.112294.