Education programs | MIPT - Moscow Institute of Physics and Technology

Research supervisor

Sergey V., Leonov

MD, PhD,
Doctor

Program description in Russian

Supervisor’s research interests

DNA repair and Aging
Mechanobiology of Cancer cells
Extracellular vesicles and cancer dissemination
New biomarkers of cancer invasiveness and radioresistance
Pharmacological modulation of EMT, stemness and radioresistance
Natural products for microbiology, oncology and aging

Supervisor’s specific requirements

BS and MS in Biology and/or Biotechnology or related disciplines

Hands-on experience with basic biochemical & biophysical methods

Proficient in the use of Microsoft Office packages

Excellent problem-solving skills, ability to work with little or no supervision and under time pressure and get results

Desirable: in-depth knowledge and motivated interest in above mentioned research of our Lab; Protein chemistry; DNA and RNA extraction, Conventional PCR, Gene Cloning (optional)

Research highlights

High Content Imaging & Analysis
Laser-Driven Ultrashort Pulsed Electron Beam & Terahertz Irradiation
Development a novel technology for the early detection of triple negative breast cancer
High Throughput Target Identification and Validation Platform for Drug Discovery
Joint projects in Oncology (Prof. Alexis GAUTREAU, CNRS, France), Biotechnology of natural compounds (UNERA Luxembourg S.A) and System Biology (Prof. Jens Schwamborn, The University of Luxembourg and Prof. Hans V. Westerhoff, VU University Amsterdam)
In vivo aging and neurodegeneration model on Caenorhabditis elegans

Main publications

Pustovalova, M.; Alhaddad, L.; Smetanina, N.; Chigasova, A.; Blokhina, T.; Chuprov-Netochin, R.; Osipov, A.N.; Leonov, S. The p53–53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure. Int. J. Mol. Sci. 2020, 21, 3342.(IF= 4.183 ).
E. Yu. Arkhangelskaya, N. Yu. Vorobyeva, S. V. Leonovb, A. N. Osipova, and A. L. Buchachenko. Magnetic Isotope Effect on the Repairof Radiation-Induced DNA Damage. Russian Journal of Physical Chemistry B, 2020, Vol. 14, No. 2, pp. 314–31. DOI: 10.1134/S1990793120020177.
Ustyantseva EI, Medvedev SP, Vetchinova AS, Illarioshkin SN, Leonov SV, Zakian SM. Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis. Stem Cell Res. 2019 Dec 4;42:101675. (IF= 3,929). https://doi.org/10.1016/j.scr.2019.101675.
Zorin V, Grekhova A, Pustovalova M, Zorina A, Smetanina N, Vorobyeva N, Kopnin P, Gilmutdinova I, Moskalev A, Osipov AN, Leonov S. Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging. Aging (Albany NY). 2019 Jul 9;11(13):4536-4546. (IF= 5.515). doi: 10.18632/aging.102067. PMID: 31289256; PMCID: PMC6660037.
Ulyanenko, S.; Pustovalova, M.; Koryakin, S.; Beketov, E.; Lychagin, A.; Ulyanenko, L.; Kaprin, A.; Grekhova, A.; M. Ozerova, A.; V. Ozerov, I.; Vorobyeva, N.; Shegay, P.; Ivanov, S.; Leonov, S.; Klokov, D.; Osipov, A.N. Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation. Int. J. Mol. Sci. 2019, 20, 2645.(IF= 4.183 ) https://doi.org/10.3390/ijms20112645
Roman Chuprov-Netochin, Elena Marusich, Yaroslav Neskorodov, Yana Mishutkina, Polina Volynchuk, Yan Ivanenkov, Alisher Touraev, Sergey Leonov, and Klaus Palme. Method for Ultrarapid High-Content Screening for Biologically Active Chemicals Using Plant Pollen. Chapter 3, in Book: Friedrich Fauser and Martin Jonikas (eds.), Plant Chemical Genomics: Methods and Protocols, Methods in Molecular Biology, vol. 1795, https://doi.org/10.1007/978-1-4939-7874-8_3, © Springer Science+Business Media, LLC, part of Springer Nature 2018.
U. R. Anumala, J. Waaler, Y.Nkizinkiko, A. Ignatev, K.Lazarow, P. Lindemann, P. A.Olsen, S. Murthy, E.Obaji, A. G. Majouga, S. Leonov, J. P. von Kries, L. Lehtiö, S. Krauss, and M.Nazaré (2017). Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. Journal of Medicinal Chemistry. Article ASAP. DOI: 10.1021/acs.jmedchem.7b00883 (IF=6.259)
E. Lashmanova, N. Zemzkaya, E. Proshkina, A. Kudryavtzeva, M. Voloshkina, E. Marusich, S. Leonov, A. Zhavoronkov, A. Moskalev. The evaluation of geroprotective effects of selected flavonoids in Drosophila melanogaster and Caenorhabditis elegans.(2017), Front. Pharmacol. 8:884 DOI: 10.3389/fphar.2017.00884 (IF=4.40)
Zorin V., Zorina A., Smetanina N., Kopnin P., Ozerov I.V., Leonov S., Isaev A., Klokov D., Osipov A.N. Diffuse colonies of human skin fibroblasts in relation to cellular senescence and proliferation. // Aging (Albany NY). 2017. V. 9. Issue 5. P. 1404-1413. doi:10.18632/aging.101240. PubMed PMID: 28522793 (IF=4.87)
A. Tsvetkova, I.V. Ozerov, M. Pustovalova, A. Grekhova, P. Eremin, N. Vorobyeva, I. Eremin, A. Pulin, V. Zorin, P. Kopnin, S. Leonov, A. Zhavoronkov, D. Klokov, A.N. Osipov. γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation. // Oncotarget. 2017. V. 8. No. 38. P. 64317-64329. https://doi.org/10.18632/oncotarget.19203 (IF=5.17)
Pustovalova M, Astrelina ТA, Grekhova A, Vorobyeva N, Tsvetkova A, Blokhina T, Nikitina V, Suchkova Y, Usupzhanova D, Brunchukov V, Kobzeva I, Karaseva Т, Ozerov IV, Samoylov A, Bushmanov A, Leonov S, Izumchenko E, Zhavoronkov A, Klokov D, Osipov AN. Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells. // Aging (Albany NY). 2017 Nov 21. doi: 10.18632/aging.101327. [Epub ahead of print] PubMed PMID: 29165316. (IF=4.87)

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